Background

THE SCIENCE OF BIOLOGICAL AGEING

Rigorous science. Meaningful biological insight.

Slow aging with the world's most accurate epigenetic test and personalized insights. 460 biomarkers, 21 organs and systems.

Become a provider

Entrophy Curve

BioNoise™
Biological Age

Going Beyond

01
Most Advanced Ageing Analysis
02
Identify Top Aging Factors
03
Grow Your Practice

Backed by World-Leading Scientists with Cutting-Edge Research

Dr. Adeel Khan, MD
Dr. Adeel Khan, MD
We are now ready for healthcare 3.0 focusing on prevention. Generation Lab is the tool that I trust.
- Dr. Adeel Khan, MD

Dr. Adeel Khan, MD

Regenerative Medicine Doctor, CEO & Founder of Eterna Health

Dr. George Church, PhD
Dr. George Church, PhD
Generation Lab's organ-level biological age test could define preventative medicine - helping us to catch aging before it leads to disease.
- Dr. George Church, PhD

Dr. George Church, PhD

The Robert Winthrop Professor of Genetics at Harvard Medical School

Dr. David Sinclair, AO, PhD
Dr. David Sinclair, AO, PhD
Irina has made significant contributions to Aging Science. Her peer reviewed paper on Nature and Science have been cited for 4000 times.
- Dr. David Sinclair, AO, PhD

Dr. David Sinclair, AO, PhD

Professor of Genetics, Harvard Medical School

Dr. Robert Langer, PhD
Dr. Robert Langer, PhD
Research proved that biological age can be controlled and reversed - not just in worms, but in humans.
- Dr. Robert Langer, PhD

Dr. Robert Langer, PhD

Professor at MIT, Co-founder of Moderna, pioneer in drug delivery and regenerative medicine

The Gold Standard in Biological Age Testing

Your full-body aging profile, decoded

21 Organ Systems, 1 Simple Test

Our proprietary 460-biomarker panel delivers the most comprehensive aging profile available today.

1. Auditory System 2. Cardiac System 3. Blood & Vascular System 4. Hepatic System 5. Muscular System 6. Skeletal System 7. Nervous System 8. Brain Health 9. Respiratory System 10. Blood Sugar
11. Immune System 12. Oncogenesis 13. Metabolism 14. Inflammatory 15. Tissue Regen 16. Fibrosis 17. Digestive System 18. Urinary System 19. Reproductive System
Auditory System Gene Symbol: KCNN1 Cardiac System Gene Symbol: DDX4 Blood & Vascular System Gene Symbol: CYP2D6 Hepatic System Gene Symbol: GLIS3 Muscular System Gene Symbol: COL18A1 Skeletal System Gene Symbol: NOTCH4 Nervous System Gene Symbol: NOTCH4 Brain Health Gene Symbol: ASH1L Respiratory System Gene Symbol: FGF1 Blood Sugar Gene Symbol: GLIS3 Immune System Gene Symbol: TOLIP Oncogenesis Gene Symbol: NOTCH4 Metabolism Gene Symbol: LBP Inflammatory Gene Symbol: SYTL2 Tissue Regen Gene Symbol: LBP Fibrosis Gene Symbol: COL18A1 Digestive System Gene Symbol: FGF1 Urinary System Gene Symbol: NOTCH4 Reproductive System Gene Symbol: DDX4 Auditory System Gene Symbol: KCNN1 Cardiac System Gene Symbol: DDX4 Blood & Vascular System Gene Symbol: CYP2D6 Hepatic System Gene Symbol: GLIS3 Muscular System Gene Symbol: COL18A1 Skeletal System Gene Symbol: NOTCH4 Nervous System Gene Symbol: NOTCH4 Brain Health Gene Symbol: ASH1L Respiratory System Gene Symbol: FGF1 Blood Sugar Gene Symbol: GLIS3 Immune System Gene Symbol: TOLIP Oncogenesis Gene Symbol: NOTCH4 Metabolism Gene Symbol: LBP Inflammatory Gene Symbol: SYTL2 Tissue Regen Gene Symbol: LBP Fibrosis Gene Symbol: COL18A1 Digestive System Gene Symbol: FGF1 Urinary System Gene Symbol: NOTCH4 Reproductive System Gene Symbol: DDX4

Clinically validated. Head-to-head tested.

Proven Accuracy Outperforming Competition

See how The SystemAge™ stacks up in direct comparisons against traditional biological age clocks— and why doctors are standing behind it.

Read Our Case Study →
SystemAge™DunedinPACEPhenoAge
Accuracy0.990.580.57
Confidence (MMC)0.970.160.14
Specificity (TNR)0.9830.5840.573
Sensitivity0.9940.5760.568
Negative Predictive Value (NPV)0.9860.5370.568
F1-score0.9930.5860.571

A Novel Way to Measure Aging

The Signal Everyone Else Is Missing.

Conventional epigenetic clocks rely on methylation levels and statistical models to predict age. But levels alone capture only the average signal, not how that signal is regulated or how it changes over time. Aging is reflected not just in the level itself, but in increasing variability in methylation patterns, a sign of declining regulatory control. A healthy 30-year-old and a 70-year-old in decline can show the same methylation level at a CpG site, yet one is stable while the other becomes increasingly disordered. The level is the same. The underlying biology is not.

Your body speaks before disease strikes. We help you listen.

Read Our Publication →
Detection
Entropy Curve

Turning health data into real decisions

From Personalised Insights to Action Plan

Most biological age tests end with a number. SystemAge™ provides a more actionable view. By assessing biological ageing across multiple body systems, it helps identify where ageing-related changes appear most pronounced—supporting more targeted, personalised interventions.

Our proprietary Intelligence Engine™ analyzes your biological age data to deliver tailored recommendations - grounded in science, designed for change.

Feature
Overlay
DNA Helix

Learn more about the 460+ biomarkers that identify causes of aging.

DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
AIRE
Autoimmune regulator gene essential for central immune tolerance by controlling thymic T-cell selection and preventing autoimmunity.
AHSG
Functions as acute-phase protein regulating immune cell activity and inflammatory responses during infection.
S100A2
Calcium-binding protein involved in immune cell activation and inflammatory signaling cascades.
TNF
Central pro-inflammatory cytokine orchestrating immune cell activation, inflammation, and host defense responses.
IL1RN
Interleukin-1 receptor antagonist providing anti-inflammatory balance during acute phase response via alternate activation.
TOLLIP
Toll-interacting protein modulating IL-1R signaling to balance innate immunity and prevent inflammatory tissue damage.
LBP
Lipopolysaccharide-binding protein recognizing bacterial endotoxins and initiating immune responses against pathogens.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.
DLGAP2
Discs large homolog-associated protein involved in synaptic organization and plasticity. Important for learning, memory, and cognitive function.
OTX1
Homeobox transcription factor essential for brain development, particularly midbrain and hindbrain patterning. Critical for neuronal differentiation and cognitive function.
CHD5
Chromodomain helicase involved in neuronal gene regulation and brain development. May play role in intellectual disability and autism spectrum disorders.

Published Research

Dive into the scientific foundation of our tests through decades of rigorous research and peer-reviewed studies published in leading journals.

Published Research

Dive into the scientific foundation of our tests through decades of rigorous research and peer-reviewed studies published in leading journals.

GeroScience
GeroScience

GeroScience - Jan 18, 2025

DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging

PubMed
PubMed

PubMed - Dec 11, 2024

The dominance of old blood, and age-related increase in protein production and noise

Aging
Aging

Aging - Sep 12, 2023

DNA methylation clocks struggle to distinguish inflammaging from healthy aging

Cell Cycle
Cell Cycle

Cell Cycle - Jun 15, 2012

DNA methylation clocks struggle to distinguish inflammaging from healthy aging

Cell Stem Cell
Cell Stem Cell

Cell Stem Cell - Jan 10, 2008

A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis

Nature
Nature

Nature - Feb 17, 2005

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Trusted by 500+ Clinics

We're honored to be the choice of the medical pioneers who use our insights to transform lives, every day.

Become a Provider
Dr. Steven Murphy, MD

Dr. Steven Murphy, MD

Pioneer in Genomic Medicine, Author & Medical Professor. “With traditional medicine falling short, there's a growing demand for personalized data to prevent illness.”

Dr. Mariel Saade, MD

Dr. Mariel Saade, MD

Specialist in Longevity Medicine

Dr. Dana Churchill, NMD

Dr. Dana Churchill, NMD

Founder of Churchill Center, Specialist of Integrated Healthcare

Peter Diamandis

Peter Diamandis

Executive chairman of the X Prize Foundation. “We're the first generation with the power to understand and slow aging, extend human healthspan. Generation Lab is at the forefront of that science.”

Dr. Steven Murphy, MD

Dr. Steven Murphy, MD

Pioneer in Genomic Medicine, Author & Medical Professor. “With traditional medicine falling short, there's a growing demand for personalized data to prevent illness.”

Dr. Mariel Saade, MD

Dr. Mariel Saade, MD

Specialist in Longevity Medicine

Dr. Dana Churchill, NMD

Dr. Dana Churchill, NMD

Founder of Churchill Center, Specialist of Integrated Healthcare

Peter Diamandis

Peter Diamandis

Executive chairman of the X Prize Foundation. “We're the first generation with the power to understand and slow aging, extend human healthspan. Generation Lab is at the forefront of that science.”

Dr. Elizabeth Yurth, MD

Dr. Elizabeth Yurth, MD

Founder of Boulder Longevity Institute

Dr. George Church, PhD

Dr. George Church, PhD

The Robert Winthrop Professor of Genetics at Harvard Medical School. "The team is taking cutting edge research straight out of the lab and applying it to a pressing issue: identifying disease much earlier than ever before possible using genetic markers. It's a pivotal moment in epigenetics and I'm excited to see what unfolds

Dr. Weiguo Li, MD

Dr. Weiguo Li, MD

Physician at Alhambra Hospital Medical Center & Garfield Medical Center

Carrie Drinkwine

Carrie Drinkwine

Owner & CEO of Institute of Regenerative Health

Dr. Elizabeth Yurth, MD

Dr. Elizabeth Yurth, MD

Founder of Boulder Longevity Institute

Dr. George Church, PhD

Dr. George Church, PhD

The Robert Winthrop Professor of Genetics at Harvard Medical School. "The team is taking cutting edge research straight out of the lab and applying it to a pressing issue: identifying disease much earlier than ever before possible using genetic markers. It's a pivotal moment in epigenetics and I'm excited to see what unfolds

Dr. Weiguo Li, MD

Dr. Weiguo Li, MD

Physician at Alhambra Hospital Medical Center & Garfield Medical Center

Carrie Drinkwine

Carrie Drinkwine

Owner & CEO of Institute of Regenerative Health

Dr. Adeel Khan, MD

Dr. Adeel Khan, MD

Regenerative Medicine Doctor, CEO & Founder of Eterna Health. “We are now ready for healthcare 3.0 focusing on prevention. SystemAge is the tool that I trust.”

Dr. Adeel Khan, MD

Dr. Adeel Khan, MD

Regenerative Medicine Doctor, CEO & Founder of Eterna Health

Natalia Naila

Natalia Naila

Certified Health Coach & Host of Wellness Is Life Podcast

Dr. Ariana Fontenot, PT

Dr. Ariana Fontenot, PT

Founder of Slight Motion PT

Dr. Adeel Khan, MD

Dr. Adeel Khan, MD

Regenerative Medicine Doctor, CEO & Founder of Eterna Health. “We are now ready for healthcare 3.0 focusing on prevention. SystemAge is the tool that I trust.”

Dr. Adeel Khan, MD

Dr. Adeel Khan, MD

Regenerative Medicine Doctor, CEO & Founder of Eterna Health

Natalia Naila

Natalia Naila

Certified Health Coach & Host of Wellness Is Life Podcast

Dr. Ariana Fontenot, PT

Dr. Ariana Fontenot, PT

Founder of Slight Motion PT

Compliance and security

SystemAge™ by Generation Lab operates to ISO/IEC 17025 standards, ensuring reliable, high-quality analysis. The platform follows GDPR- and HIPAA-aligned data protection principles and can be delivered as a white-label solution for scalable preventive health and longevity programs.